Scientific Program

Day 1 :

  • Young Researchers Forum
Speaker
Biography:

Adel Elmekes is a PhD student at Cadi Ayyad University - Faculty of Sciences Semlalia, Marrakesh-Morocco. The main goal of his thesis focuses on the study of The clinical and epidemiological risk factors of infections due to multi-drug resistant bacteria in an adult intensive care unit of University Hospital Center (UHC) in Marrakesh-Morocco and the screening of  new antimacrobial agents against  hospital multidrug resistant bacteria from acinobacteria isolates. He is responsible for hospital hygiene unit and active member of the committee against nosocomial infections.

Abstract:

The objective of this study is to analyze the qualitative and quantitative microbial composition of the environment of high risk infectious units at the Ibn Tofail hospital, CHU Mohammed VI, Marrakech. This is a prospective study carried out at four units (two operating units, two adult intensive care units Intensive Care Unit (ICU) of CHU Mohammed VI Marrakech during a period of four months. The samples concerned inanimate surfaces and the hands of different staff. The level of antibiotic resistance was studied by the diffusion method agar medium. The choice of antibiotics and the criteria for interpretation of the antibiogram were made according to the standards of the European Committee on Antibiograms (EUCAST). More than 95 bacterial strains were isolated from the 125 samples. The antibiotic resistance profile showed that 46% were multidrug resistant strain, 19% of them were Acinetobacter baumannii resistant to imipenem (ABRI), 17 % of the Enterobacteriacae producing extended spectrum of beta-lactamase (ESBLE), and 8 % were methicillin-resistant Stapylococcus aureus (MRSA). The lowest rate (4%) was obtained for Pseudomonas aeruginosa resistant to carbapenem (PARC). The ABRI was mainly found in the inanimate surfaces of ICU, the EBLSE were predominant in the surfaces of the operating units. However, the MRSA was isolated mostly from the staff handprints and the surfaces of the four studied units.The alarming presence of MDR bacteria in the hospital environment urges the hospital actors (biologists, hygienists, clinicians and nursing staff) to double their efforts to control these bacteria.

  • Chronic Diseases | Diabetology & Metabolic Diseases | Cardiovascular Diseases | Chronic Diseases Diagnosis

Session Introduction

Sasha Shafikhani

Rush University Medical Center, USA

Title: Molecular mechanisms underlying impaired infection control in diabetic ulcer
Speaker
Biography:

Dr. Sasha Shafikhani completed his undergraduate and PhD studies at University of California at Berkeley and postdoctoral studies at University of California at San Francisco. Dr. Shafikhani is currently an Associate Professor in the Department of Medicine at Rush University Medical Center. He serves on editorial board of six reputed journals. As a cellular microbiologist, his group conducts projects that involve bacterial pathogenesis, cancer biology, and chronic wound healing. The primary focus of his laboratory is: (i) to determine the virulence mechanisms in the bacterial pathogens, particularly Pseudomonas aeruginosa; (ii) to determine the eukaryotic host responses that are intended to control bacterial pathogen infections; and (iii) to employ bacterial toxins as molecular tools to dissect important mammalian cellular processes such as cytokinesis, apoptotic program cell death, and apoptotic compensatory proliferation signalling.

Abstract:

Statement of the Problem: Enhanced bacterial infection and microbiome shift toward pathogenic bacteria are major co-morbidities that contribute to impaired healing in chronic diabetic foot ulcer. The underlying reasons for the impaired infection control in diabetic wound remain poorly understood. Methodology & Theoretical Orientation: We used the cutaneous full-thickness wound models in STZ-injected type 1 diabetic (T1D) rats and db/db T2D mice, to study the early dynamics of bacterial infection control in normal and diabetic wound tissues. Findings: We have found that unlike chronic diabetic ulcers which suffer from persistent unresolving inflammation, the acute phase of inflammatory response- which is needed to counter invading pathogens early after injury- is significantly delayed in diabetic wounds, rendering these wounds susceptible to bacterial infection and healing impairment. Our data further suggest that normal wound tissues express pathogen-specific antimicrobial peptides (ps-AMPs) that preferentially target pathogenic bacteria amongst commensals by recognizing specific virulence structure(s) that are only found in pathogenic bacteria. In contrast, pathogen-specific antimicrobial defenses are impaired in diabetic wounds, thus setting the stage for the microbiome shift toward pathogenic bacteria. We further show that the inability to control pathogenic bacteria leads to persistent inflammatory state and impaired healing in diabetic wound. We have found that inadequate chemokine expression in diabetic wound early after injury leads to delayed inflammatory response, which in turn results in reduced ps-AMPs, rendering diabetic wound vulnerable to infection with pathogenic bacteria, which exacerbate wound damage and drive diabetic wound toward persistent unresolving inflammatory state. Importantly, we show that jumpstarting inflammatory responses in diabetic wound early after injury resorts antimicrobial defenses and promotes healing in diabetic wound, indicating that inadequate inflammatory response early after injury in diabetic wound is just as harmful as the persistent inflammatory state that dominates these wounds as they become chronic.

Speaker
Biography:

Ousman Bajinka holds a Master degree in Microbiology from Ege University. He has his bachelors from the University of The Gambia in biology and chemistry. Ousman has worked with Medical Research Council (MRC) Gambia Unit as a medical laboratory technician and has series of lab experiences before joining MRC. He has 4 years teaching experiences and this includes national and international.

Abstract:

In this generation among the fast killing diseases, cancer is not a small factor. There has been and still intensive study on the occurrences and mechanism of cancer. Due to the fact that there has not been any scientifically proven treatment that specific to the various forms of cancer, the controversies as to what cause this cancers are exponentially high. One of this is the concept of trans-fat containing foods are causing cancer. Trans-fat foods up to date are believed by many that is a causing cancer instead of a risk to cardiovascular diseases. In this review, some concrete facts are further looked into to defeat the idea of trans-fat as carcinogens. Cancer itself is thoroughly explained and types of cancers in relations to the sources of foods that are claimed high risk. The chemistry of saturated and unsaturated fatty acids was also dealt with and foods that are proven to be rather protective to causing cancer are also highlighted. None the less, the reasons why trans-fats were term carcinogens was explained and disproved. Among the review article, there has not any scientific proof as to trans fats as carcinogenic instead a risk to heart diseases and for this, extensive use of these food items are advised to be less consumed.

Speaker
Biography:

Laurice Fretwell and Meredith Wilkinson come from diverse research backgrounds (cardiovascular pharmacology & psychology, respectively), but have recently joined forces over their shared passion for delineating the causes of, and links between, chronic cardiovascular disease and mental health. Their different methods of research, when combined, enable them to provide a fresh approach to problem-solving. As part of this new partnership, they are supervising a Masters by Research student, Sumaya Shire, who has a background in clinical physiology. This research is part of wider project that aims to identify barriers faced by local ethnic minority groups when accessing support and care for cardiovascular and mental health issues.

Abstract:

Purpose: This systematic review examines the factors/barriers which prevent ethnic minority patients from accessing or completing their cardiac rehabilitation programmes. Background: Cardiac rehabilitation has been shown to improve physical health, encourage healthier lifestyles and decrease cardiac mortality and morbidity. However, despite these benefits ethnic minority patients often have the lowest attendance rates in comparison to the rest of the population. This review is exploring why this is and what can be done. Methods: A systematic review following barriers which prevent ethnic minority patients from attending and completing their programmes were analysed. For this review, only primary research papers (qualitative and mixed methods studies) were considered. We excluded systematic and literature reviews, perspective papers and meta-analysis. There were no restrictions placed in terms of country and date of publication. Around 387 journals were found through selected search terms, which were then analysed through the CASP framework model. Currently, over 10 journals have been analysed and their themes identified below. Conclusion: Six overarching themes have been identified in assessing the lack of uptake and upkeep of cardiac rehabilitation amongst ethnic minority patients: (1) Language barriers, (2) knowledge of cardiac rehabilitation services, (3) accessibility, (4) fatalistic health beliefs, (5) gender, cultural and religious influences and (6) support. Changes in the management of these services can help to eliminate the above barriers.

Speaker
Biography:

Kiran Fatima Lab Technician at Department of Biosciences Sheheed Zulfikar Ali Bhutto Insititute Of Sciences & Technology (SZABIST) karachi campus Pakistan,has done Master in Physiology from University Of Karachi.She had been a Visiting Faculty in SZABIST she is also working in different reearch project like,isolation,chahracterization and purification of various enzymes from microbial source.

Abstract:

Background and objectives: Helicobacter pylori, was found to be an important factor in the pathogenesis of peptic ulcer disease, gastritis, and gastric malignancy. The growing problem of antibiotic resistance by the organism in Pakistan thus demands the search for novel compounds, especially from natural sources as in this study; we screened the aqueous extracts of Camiella sinensis and also compared the anti bacterial efficacy of its non-fermented, semi -fermented and fermented products. Methods: All these biopsies were processed for detection of H.pylori by two rapid Helicourease – indigenously developed rapid urease detection kits, culture and polymerase chain reaction (PCR).The 5% aqueous extract of  fermented, semi fermented and non-fermented Green tea was prepared and their antibacterial potential was explored against 35 clinical isolates of H. pylori agar well diffusion technique.  The Minimum Inhibitory Concentration (MIC) of the most susceptible tea products were also carried out by Micro-dilution method for the sake of comparison. Results: Most of the screened H .pylori isolates were resistant to more than one of the antibiotics like metronidazole and clarithromycin. Significant activity was obtained in non-femented green tea with an average zone of inhibition along with MIC was around 32 mm , semi fermented product showed 28 mm.Conclusion:Results indicated that all forms of G. tea extracts possessed some variable level of anti H. pylori activity. But non fermented that is freshly plucked g.tea leaves with out any industrial treatment  have profound effect with least MIC and thus considered as a suitable candidate for the eradication of H.pylori drug resistant species.

Yacob Mathai

Marma Heatth Centre,India

Title: The Purpose of Temperature of Fever
Speaker
Biography:

Dr. Yacob is a practicing physician in the field of healthcare in the state of Kerala in India for the last 29 years and very much interested in basic research. His interest is spread across the fever, inflammation and back pain. He is a writer. He has already printed and published nine books in these subjects. He has written hundreds of articles in various magazines. He has presented 9 research papers in Indian Science Congress 2008 to 2017.And 2 papers selected for the coming 2018 Indian science congress. He has presented 2 papers in Kerala science congress2014and 2017. After scientific studies for a long time, they have developed a theory, which proves the temperature of fever is to increase blood circulation. They have developed 8000 affirmative cross checking questions. It can explain all queries related with fever and it considers the messages of the body and the facts of physics

Abstract:

When the disease becomes threat to life or organs blood circulation decreases, Temperature of fever will emerges to increase prevailing blood circulation. And it acts as a protective covering of the body to sustain life. When blood flow decrease to brain, the patient becomes fainted delirious. If we try to decreases temperature of fever, the blood circulation will further reduced. Blood circulation never increases without temperature increase. Delirious can never be cured without increase in blood circulation. The temperature of fever is not a surplus temperature or it is not to be eliminated from the body. During fever, our body temperature increases like a brooding hen`s increased body temperature. The actual treatment to fever is to increase blood circulation. Two ways to increase blood circulation 1. Never allow body temperature to lose 2. Apply heat from outside to the body. When the temperature produced by body due to fever and heat which we applied on the body combines together, the blood circulation increases. Then body will stop to produce heat to increase blood circulation. And body will get extra heat from outside without any usage of energy. How can we prove that the temperature of fever is to increase blood circulation? If we ask any type of question related to fever by assuming that the temperature of fever is to increase blood circulation we will get a clear answer. If avoid or evade from this definition we will never get proper answer to even a single question. If we do any type of treatment by assuming that the temperature of fever is to increase blood circulation, the body will accept, at the same time body will resist whatever treatment to decrease blood circulation.  No further evidence is required to prove the temperature of fever is to increase blood circulation. 

Speaker
Biography:

Abstract:

Background:It is clear through the literature and newly implemented regulations that  the involvement of End-Users in the development of medical device technologies (MDTs) is a matter of growing interest. Many advantages are perceived by this involvement like an easier implementation, a faster acceptance, a lower resistance to technology and an overall safer healthcare services provided. However, this involvement is often perceived by manufacturers as imposed and its application comes with a series of barriers. In this research we will try to identify manufacturers’ perceptions regarding this involvement and underline their concerns and vision. Methods: We conducted in-depths semi-structured interviews with 22 participants representing major MDT manufacturers key-players in the field. Each interview lasted an average of 1h and 15 minutes and participants were asked about their perception regarding End-User involvement in MDT Development processes, ranging from the criteria of selection of the End-Users, the forms of involvement, the potential impact of this involvement as well as the barriers, concerns and skepticism regarding it. Results:It is clear that even though the involvement of End-Users in MDT Development process is often considered as a positive step towards safer healthcare services, manufacturers still show some form of skepticism towards this initiative. They question End-Users’ maturity and prefer to deal with “lead-users”, they point out several barriers in regards to project duration, costs, administrative complications, but admit advantages regarding an easier subsequent implementation of MDTs and an easier acceptance of their outcome in the market. Conclusion: End-Users’ involvement in MDT Development processes is still conducted in an ad-hoc manner but its standardization can be promising and contribute towards an optimization of the development processes. Additional works have to be done mainly regarding End-Users selection criteria, levels of involvement and forms of implication.

Speaker
Biography:

Francisco Jose Amo Setien  gained a PhD in Health Sciences (University of Cantabria, UC) in 2017, holds an inter-university Master's Degree in "Genetic, nutritional and environmental conditioning factors of growth and development" (UC) and a Nursing Degree (UC). Francisco Jose has gained research experience in the field of nutrition, obesity in children and adolescents with intellectual disabilities, as well as in health related quality of life in patients with chronic diseases, and he has been a full-time teaching assistant in the area of community health in the nursing department of the University of Cantabria since 2014.

Abstract:

Chonicity management is the greatest challenge that the Spanish national health system faces, having to invest 80% of health expenditure to deal with this problem. Complex chronic patients (CCPs) are those patients in which several chronic pathologies coexist with frequent decompensation and high risk of functional loss. CCPs represent between 3-5% of the Spanish population and consume a high percentage of the resources. Objective: To describe the level of dependence and cognitive impairment experienced by chronic complex patients in the urban area of Santander (Cantabria) and Palma (Balearic Islands). Methods: A multicenter, cross-sectional study involving over 18-year-old CCPs located at 3-4 level of the risk pyramid in the care model to chronicity. They are located   in the urban area of Primary Care in Santander (Cantabria) and Palma (Balearic Islands).  Barthel Index was used to assess dependence and cognitive deterioration was assessed through the Pfeiffer test. Results: 20 Health Centers from Santander (n = 2885) and 16 from Palma (n = 1631) participated in the study. The average age of the selected chronic patients was 77 years (SD = 12.3). 27.4% presented moderate, severe or total dependence and 23.6% moderate or significant cognitive impairment. A linear relationship was observed between the scores in the Pfeiffer test and the Barthel index (r=-0.47, p <0.001). The hospital admission rate correlated with the score in the Pfeiffer test (r = 0.2, p <0.001) and in the Barthel index (r = -0.19, p <0.001). Conclusions: Age, dependency level, cognitive deterioration and hospital admission rate are intimately related in complex chronic patients. Therefore, it is important to continue promoting care models aimed at reducing dependency.

Abstract 2: A systematic review and meta-analysis of nursing interventions in patients with chronic diseases

Nurses often perform interventions aimed at improving the health-related quality of life (HRQOL) in patients with chronic diseases. However, the amount of information generated, sometimes contradictory, makes it difficult to interpret the results. This systematic review allows empirical evidence to be summarized. Thus, the purpose of this study is to determine, through a systematic review and a meta-analysis, the characteristics of the nursing interventions, performed in people/patients over 18 years old with chronic diseases, which involve an improvement in their HRQOL. A literature search was performed in six electronic databases (Pubmed, Scopus, WOS, CINAHL, Web of Science and Cochran) from September until December 2017. Also, bibliographies of relevant papers and publications were hand searched. Study Selection: Randomized controlled trials (RCTs) and cluster-RCTs, with at least two groups of patients in which a nurse was involved. Data Extraction and Synthesis: Two authors independently reviewed studies for inclusion, extracted data, and assessed study quality with discrepancies being solved through discussion. In the meta-analysis, Effect Sizes (ESs) were calculated for each outcome by calculating the standardized mean change for each sample. Findings: This systematic review synthesizes data from 38 studies, published between 2003 and 2015, that provided a sample of 6480 people with a mean age of 68.4 years (SD = 8.7). In 60.6% of the interventions a single component was used, being education the one most commonly used. 72.5% of the interventions were not based on a theory. The duration of the interventions ranged from 4-104 weeks, with a mean of 12 sessions and 54.2 minutes/session. SF-36 questionnaire was the most often used to evaluate HRQOL. After the intervention, most of the studies showed a slight HRQOL improvement (ES = 0.1) in the intervention group. Conclusions: Nurses interventions had a little, but significant beneficial effect on HRQOL.

Speaker
Biography:

Master Degree in Enzymology (1991) and PhD in Microbiology in 1994, both from the university Aix-Marseille II France. I had a postdoctoral position in the Pr. Roy Riblet’s laboratory (San Diego U.S.A.) working on the physical map of the C57BL mouse Igh locus. In 1997, I had a second position in the Pr. Alain Dessein’s laboratory (Marseille) working on the identification of genetic factors that control infection and severe disease in Schistosomiasis. Since 2010, I am developing in collaboration with several Brazilian groups some programs to identify human susceptibility genes for chronic Chagas cardiomyopathy. The outcome of Chagas disease is ultimately, defined in the patients’ hearts, as a consequence of inflammation and myocardial tissue response. We thus hypothesize that expression of many pathogenetically relevant genes and proteins in the myocardial tissue of CCC patients is controlled by genetic polymorphisms. A host genetic signature may have a prognostic value.

Abstract:

Mechanisms underlying differential progression to chronic chagas cardiomyopathy (CCC) are still incompletely understood. The outcome of infection in a particular individual is the result of a set of complex interactions among environmental, social factors, the genetic of the parasite strains and the host genetic background. The outcome of Chagas disease is ultimately defined in the patients’ hearts, a consequence of inflammation and myocardial tissue response. We thus hypothesize that expression of many pathogenetically relevant genes and proteins in the myocardial tissue of CCC patients is controlled by genetic polymorphisms. The corollary is that it may be possible to establish a host genetic signature with prognostic value based on such polymorphic genes. For that matter, we will use a systems biology approach to identify 1) genes/proteins that are differentially expressed in CCC myocardium 2) functional polymorphisms that may control their expression or function. First of all, we have identified differentially expressed genes and proteins in fresh-frozen CCC heart samples. Methylation analysis and miRNA profiling were performed to identify epigenetic regulations. The second objective is the identification of genetic variants associated to disease. The first approach we are doing a GWAS analysis on a case-control cohort to identify loci and common SNPs associated to disease susceptibility. We will also characterize multicase nuclear families (including CCC and asymptomatic sibs) by exome sequencing, to identify rare functional variants shared only by the cases but not by the internal controls. Functional analyses will assess whether SNPs affect gene expression, function or protein structure. The identification of these marker sets will have a combined prognostic value for disease progression at the individual patient level, allowing close follow up and early treatment of those carrying high-risk genetic signatures. Moreover, this study will help to decipher mechanisms underlying chronic disease progression.

  • Neuro-degenerative Diseases | Cancer | Environmental Approaches | Chronic Osteoarticular Diseases

Session Introduction

John Wodarski

The University of Tennessee, USA

Title: The Integrated Behavioral Health Service Delivery System Model
Speaker
Biography:

Abstract:

Costs and effective management of health care in general, and behavioral health care in particular, have been of primary importance and concern to federal, state, and local governments.  With the passage of Health Care Reform (HCR) these concerns will only escalate.  Thus, the necessity for the development of innovative, successful, and integrated cost-effective treatments and procedures is evident.  The Behavioral Health Care Model presented here is proposed to address these needs.  The Model centers on the composition of effective psychosocial treatment and provides a cost analysis of social work and its services.  By defining the problems that need to be addressed in health care management and cost containment, and through applying findings of evidence based studies this paper provides an effective model for health care organizations.  It also presents a profile of the behavioral health social worker, defining the requisite abilities for effectiveness in the role and looking at the key impact areas for a behavioral health model.  This comprehensive guide will prepare new social workers entering health care organizations as well as provide a valuable reference for existing social workers, academics, and practitioners of behavioral health care.

Speaker
Biography:

Abstract:

The main goal of “total therapy” studies has been to establish a significant cure rate for childhood acute lymphocytic leukemia. The principle features of these studies have included administration of maximum tolerated combination chemotherapy and “prophylactic” central nervous system (CNS) irradiation. In the first three studies, a 17% 7-year leukemia-free remission rate was attained. The number of patients in complete remission decreased exponen- tially until 2 to 3 years, but stabilized thereafter. Complete remission duration was the earliest and most accurate indicator of long-term leukemia-free re- mission. In Study v, more aggressive CNS therapy was given and over half the patients have been in continuous complete remission for 3 to 4 years. Similar results are emerging in subsequent studies which also employ aggressive “prophylactic” CNS therapy. Therapy was stopped after 2 or more years of complete remission in 42 patients in “total therapy” studies, and nine have relapsed. Six of the nine had not received “prophylactic” CNS irradiation. If current trends in these studies continue, we can expect a 50% long-term leukemia-free remission rate. Thus, with currently available modalities of therapy, the prospects for cure appear bright.

Speaker
Biography:

Abstract:

Nutritional status is a sensitive indicator of community health and nutrition among preschool children, especially the prevalence of undernutrition that affects all dimensions of human development and leads to growth faltering in early life. The present study is an attempt to assess the food intake pattern and nutritional status of pre- school Chakma tribe children. It was a Cross sectional community based study. The subjects were selected purposively. This study was conducted at sadar upazilla of Rangmati. Rangamati is located in the Chittagong Division. Anthropometric data height and weight of the study subjects were collected by standard techniques. Nutritional status was measured using Z score according WHO classification.  χ 2 test, independent t test, Pearson’s correlation, Multiple regression and logistic regression  was performed as P<0.05 level of significance. Statistical analyses were performed by appropriate univariate and multivariate techniques using SPSS windows 11.5. Moderate (-3SD to <-2SD) to severe underweight (<-3SD) were 23.8% and 76.2% study subjects had normal weight for their age. Moderate (-3SD to <-2SD) to severe (<-3SD) stunted children were only 25.6% and 74.4% children were normal and moderate to severe wasting were 14.7% whereas normal child was 85.3%. Significant association had been found between child nutritional status and monthly family income, mother education and occupation of father & mother. Age, sex and incomes of the family, education of mother and occupation of father were significantly associated with WAZ and HAZ of the study subjects (P=0.0001, P=0.025, P=0.001 and P=0.0001, P=0.003, P=0.031, P=0.092, P=0.008). Maximum study subjects took local small fish and some traditional tribal food like bashrool, jhijhipoka and pork very much popular food among tribal children. Energy, carbohydrate & fat intake was significantly associated with HAZ, WAZ, BAZ and MUACZ. This study demonstrates that malnutrition among tribal children in Bangladesh is much better than national scenario in Bangladesh. Significant association was found between child nutritional status and family monthly income, mother education and occupation of father & mother. Most of the study subjects took local small fish and some traditional tribal food. Significant association was also found between child nutritional status and dietary intake of energy, carbohydrate & fat.

Speaker
Biography:

Shahverdi is a MD medical graduate (2016), who commenced his interest in Blood transfusion, cancer treatment and research in 2014. He completed a MD postgraduate qualifications before taking up positions in transfusion in Iranian Blood Transfusion Organization (IBTO) and then in cancer treatment and research in MAHAK Pediatric Cancer Treatment and Research Center and Pediatric Growth and Development Research Center of the Institute of Endocrinology and Metabolism. He became Medical researcher of the Immunohematology Reference Laboratory of the Iranian Blood Transfusion Organization in 2014 before moving to the High Institute for Research and Education in Transfusion Medicine in 2015 and Pediatric Growth and Development Research Center of the Institute of Endocrinology and Metabolism in 2017, where he is now a clinical researcher in the Department of Immunohematology and endocrinology and metabolism. Dr E. Shahverdi has been a Council member of the Blood and Cancer Research Center of the MAHAK Pediatric Cancer Treatment and Research Center and Pediatric Growth and Development Research Center of the Institute of Endocrinology and Metabolism. He is Chairman of the department of Young Doctors and Researchers of the IPHOS and Pediatric Growth and Development Research Center of the Institute of Endocrinology and Metabolism. His experience covers all areas of transfusion medicine research. He was secretary of the Young Researchers Panel of different national and international hematology and oncology congress for 5 years and chaired theirs Scientific Committee. Additionally, he has served on many other transfusion related organizations. He has written over 60 scientific papers and is in demand as a speaker to a number of international congress. He has a particular interest in the transfusion services of developing countries and has travelled to many of them to lecture and assist in practical workshops. Over the years, he has been awarded life memberships of various organizations and has won several prestigious awards from medical societies. He is now very active in various community support organizations. His main interest is now in medical history and writing.
 

Abstract:

Background and aim: Leukemia has the highest incidence in paediatric malignancy and ALL is the most common. In the recent years, treatment has been remarkably improved and now most of the patients are cured successfully. UK ALL-X is a protocol with 1 or 2 consolidation therapy phase regarding to the patient’s conditions. The aim of this study was to investigate the response to therapeutic procedure and complications related to consolidation therapy phase in this protocol.Material and Methods: In this retrospective cross sectional study, ALL Patients from 2008 to 2015 in Bahrami pediatric hospital, Iran were enrolled. Patients' demographic information and clinical characteristics, including age, gender, ALL morphology subtype, WBC and neutrophil caunts, Hb level, length of hospitalization and outcome were collected.Results: Sixty seven ALL patients who were under UK ALL-X protocol, were enrolled for analysing. 28 (41.7%) and 19 (28.3%) cases were between 0-5 and 10-15 years old respectively. 44 patients )65.6%) were boys and 23 cases (34.4%) were girls. 7 patients (10.7%) relapsed in the 3 years of diagnosis. 50 subjects (74.6%) had an overall survival of 3 years. 47% of mortalities occurred in 0-5 years old patients. 45 (67.2%) and 17 (51.5%) of patients were L1 and L2 respectively. Among 33 cases received the first phase of consolidation, 17 patients (51.5%) had experienced neutropenia. Neutropenia happened in 19 patients among 35 cases (54.2%) who received the second line therapy. There was no report of mortality caused by neutropenia subsequent to consolidation. There was no significant association between age and mortality and neither age and incidence of neutropenia subsequent consolidation therapy. Conclusion: Considering 3 year survival, no mortality report related to consolidation-therapy-induced neutropenia and low percentage of relapse in this study can suggest that this protocol is an appropriate treatment strategy in countries such as Iran.

Vincent Dumez

Co-director, Centre of Excellence on Parternership with Patients and the Public (CEPPP) University of Montreal

Title: Patient expectations for a necessary revolution in collaboration practices
Speaker
Biography:

Mr. Vincent Dumez holds a finance degree and a master in science of management from Montreal’s international business school Hautes Études Commerciales (HEC).  Up until 2010, Mr. Dumez was an associate in one of Montreal’s most influential consulting firm where he acted as a senior strategic consultant. Suffering from severe chronic diseases for more than three decades, M. Dumez has been actively involved in the development of the ‘patient partner’ concept at Montreal University. This involvement has come forward through the completion of his masters dissertation on patient-doctor relationship, his contribution to the training of patients, his work on boards of healthcare organizations and his involvement as keynote speaker in healthcare conferences. Since 2010, Mr. Dumez has developed the patient partnership program at the Faculty of Medicine. He’ now co-leading the Centre of Excellence on Partnership with the patients and Public.

Abstract:

One of the most important consequences of the increase in chronic diseases, and certainly one of the most underestimated, is their impact on collaborative practices between patients and healthcare professionals. From the context of chronic diseases emerges healthcare relationships that are long-term, with knowledgeable patients and families who themselves take charge of a large part of the care process at home, outside of clinical settings. These patients and families also have access to ever-increasing medical information via the internet, social networks or even by creating their own clinical data. For example, as of July 2018, Quebec citizens will have access to their personal data on medical tests such as radiology and blood samples, prescriptions, etc. In summary, a major patient revolution is taking place that requires a consideration of the patient as not only being at the 'centre of care' but above all as a full 'partner in care'. This shift has dramatic consequences on the way we manage the whole healthcare system from the education of health professionals and citizens, to the management of hospitals/clinics, to the governance of our healthcare institutions, health research priorities and healthcare policies.

A patient, Mr. Vincent Dumez, whom has had several chronic diseases since birth, will present this keynote speech. He will describe this revolution through his perspective as a patient partner in the context of hemophilia and HIV, but also as co-leader of the Centre of Excellence on Partnership with Patients and the Public at the University of Montreal. This Centre has been driving since 2010 a major transformation in patient partnership throughout Quebec, with impacts also at the Canadian and international level.

Speaker
Biography:

Haluskova Balter Ivana, active medical professional specialised in infectious diseases, internal medicine covering various therapeutic axes, certified in Immunology and Pediatric, MBA in vaccinology and years of clinical practise contributing to bring innovative science and diplomacy for global health (Switzerland) and most importantly to set up intelligent partnership borderless. Lived multi-country medical “field “experience in Southeast Asia, West/Central/East Europe and Middle East. Over 15 years of experience in pharmaceutical research and development for European and USA companies as Medical lead /Director of R&D in various therapeutic areas and as Scientific and Medical independent consultant for various stakeholders globally. Active as speaker on various congresses to bring science to clinic, member of French immunology society (SFI) administrative board and several international academic societies (focus on innovation of R&D reflecting immunology and genetic variability, role of immunologic approach for treatment and diagnostic, tackle problem of resistance for antimicrobials, antimalarial, antivirals etc). Member of advisory Health concern (India) and think tank group in order to attract attention to role of accessible medical care, education and awareness along with accurate diagnostic and innovative partnership in this area. Years of expertise to work globally but recently more focused on France and BRICs and Asia (India and Russia in particular) as Medical advisor for scientific partnership, bringing new innovative concepts alive and getting them endorsed.

Abstract:

The gut-brain axis  consists of bidirectional communication between the central and the enteric nervous system, linking emotional and cognitive centers of the brain with peripheral intestinal functions. This interaction between microbiota  appears to be bidirectional, namely through signaling from gut-microbiota to brain and from brain to gut-microbiota by means of neural, endocrine, immune, and humoral links. It is already well known that interactions between the immune and nervous systems play an important role in modulating host susceptibility and resistance to inflammatory disease. Neuroendocrine regulation of inflammatory and immune responses and disease occurs at multiple levels.  While many genes and environmental factors contribute to susceptibility and resistance to autoimmune/inflammatory diseases, a full understanding of the molecular effects on immune responses of combinations of neuropeptides, neurohormones and neurotransmitters at all levels has opened up new therapeutic approaches and are essential for the design of future therapies based on such principles. Influence of our microbiota on immunity and metabolism, more recent researches  suggest that microbes impact many different brain functions and could be potentially involved in several neuropathologies including neurodegenerative diseases like sclerosis multiplex and Alzheimer’s disease(AD). Bacteria populating the gut microbiota can secrete large amounts of amyloids and lipopolysaccharides, which might contribute to the modulation of signaling pathways and the production of proinflammatory cytokines associated with the pathogenesis of AD. Imbalances in the gut microbiota can induce inflammation that is associated also with the pathogenesis of obesity, type 2 diabetes mellitus, and Alzheimer’s disease. Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota and recent results offer functional evidence that human microbiome components contribute to CNS-specific autoimmunity. evidence that human MS-derived microbiota contain factors that precipitate an MS-like autoimmune disease in a humanized transgenic mouse model. This observation provides possibilities for characterizing the precise role and functional mechanisms by which the human intestinal microbiota contributes to the pathogenesis of neuroinflammatory diseases. The findings may eventually have important implications not only for the pathogenesis but also for the therapy and potentially even prevention of human MS. Futher research moving forward to see potential intervention knowing that modulation of the gut microbiota might be one promising therapy for MS. Oral treatment with ECN(Escherichia coli strain Nissle 1917), but not with the archetypal K12 E. coli strain MG1655, reduced the severity of EAE (experimental autoimmune encephalomyelitis). This beneficial effect was associated with a decreased secretion of inflammatory cytokines and an increased production of the anti-inflammatory cytokine IL-10 by autoreactive CD4 T cells, both in peripheral lymph nodes and CNS. Interestingly, ECN-treated mice exhibited increased numbers of MOG-specific CD4+ T cells in the periphery contrasting with severely reduced numbers in the CNS, suggesting that ECN might affect T cell migration from the periphery to the CNS through a modulation of their activation and/or differentiation. In addition, we demonstrated that EAE is associated with a profound defect in the intestinal barrier function and that treatment with ECN. Futher research to explore diagnosis and treatment of CNS diseases and link with human microbiota and crosslinks with immune system and CNS translated to innovative approaches promise to bring innovative solutions for patients benefit.

  • Chronic Respiratory Diseases | Microbial Role in Chronic Illness | Epidemiology
Speaker
Biography:

Currently, assistant professor in microbiology and immunology at Omdurman Islamic University, Faculty of Medical Laboratory. I have  been appointed as  the  Associate  Editor of  Journal of Blood Disorders, Symptoms & Treatments, Canada.  I have been served as  Associate  Editor of     Sudan medical laboratory Journal (SMLJ). I have  been appointed as  member in the   Editorial board of Allergy and Immunology Journal.

Abstract:

The research studies the etiology of Leukemia. No single known cause for all of the different types of leukemia exists. Controversial hypotheses was proposed suggesting the role of physical as well as chemical and even biological factors as being responsible for Leukemia incidents. The actual cause of Leukemia which is a serious cancer in Sudan is still under scrutiny. We hypothesized that EBV could be involved in the etiology of leukemia. We describe here the results of our attempt to find a possible link between leukemia and EBV. It is generally accepted that the (EBV) is an important etiologic factor in various tumors. Virtually little was reported about the relationship between EBV genes and leukemia. However, no full-length analysis of any substrain of EBV in Sudan area has been reported. The main objective of this study is to assess the incidence and the significance of EBV in patients with leukemia disorder using diagnostic parameters including cell morphology, immunologic markers, and molecular investigations.  Our findings provided evidence of the involvement of EBV in patients with leukemia. The results suggested that EBV DNA genome encoding the non-glycosylated membrane protein BNRF1 pl43 was observed in a significant proportion of patients with ALL. We could not exclude a correlation between these viral infections and later leukemogenesis in childhood ALL in Sudan. Further investigation on the link between maternal EBV reactivation and the development of ALL in offspring needs to be explored.  Neither latent infection nor congenital infection could be excluded.

Speaker
Biography:

Fatemeh Malekdar is a research assistant at the Razi Vaccine and Serum Research Institute. Her main research interests are in FMD virus. She is currently working on a MSc thesis on the Designing Indirect ELISA Test for Detection of Antibodies against Serotype A2013 and O2010 of Foot and Mouth Disease (FMD) Virus in Cattle.The research is supervised by Professor Homayoon Mahravani in FMD department.

Abstract:

Foot and Mouth Disease (FMD) Virus is a contagious animal disease that causes irreparable damage to the economy of a country, including Iran where the disease is native to. Among the ways to combat FMD is vaccination and slaughter. Because of the specific situation of Iran, it is rather not possible to kill infected animals. Therefore, vaccination seems to be the most important way to fight the disease. The methods used to evaluate the safety and determine the titer of antibody in a serum are mainly serum neutralization test (SNT) and enzyme linked immunosorbent assay (ELISA). In this research, designing an indirect ELISA test based on coating of 140S complete viral particles makes it possible to determine antibody and following the fact that determining serotype and viral type does not require time-consuming and complex molecular tasks, including gene expression. In addition, in the event of a new epidemic, a new epidemic condition can be detected by using serum antibody method. However, coating complete viral particle leads requires virus purification as well as anti-immunoglobulin conjugate antibody testing of the same animal. In this study, SNT test was used as a Gold Test to determine the serum antibody level and its results was compared with indirect ELISA method to determine the sensitivity and specificity of the indirect ELISA test for measuring the anti-virus antibody rate of type (A2013) FMD through ROC analysis, with 100% sensitivity and the specificity of 90% sensitivity, using routine formulas with 100 sensitivity and specificity of 82%. In this study, considering a cut off OD = 0.3, there was a significant difference between the vaccinated animals and the unvaccinated animals in terms of antibody level against the A2013 type. This indicates the correctness of the test and the accurate and proportional antibody detection against the under study viral types of FMD.

Speaker
Biography:

Segundo Mesa Castillo. As Specialist in Neurology, he worked for 10 years in the Institute of Neurology of Havana, Cuba.  He has worked in Electron Microscopic Studies on Schizophrenia for 32 years. He was awarded with the International Price of the Stanley Foundation Award Program and for the Professional Committee to work as a fellowship position in the Laboratory of the Central Nervous System Studies, National Institute of Neurological Diseases and Stroke under Dr. Joseph Gibbs for a period of 6 months, National Institute of Health, Bethesda, Maryland, Washington D.C. USA, June 5, 1990. At present he is member of the Scientific Board of the Psychiatric Hospital of Havana and give lectures to residents in psychiatry.

Abstract:

There is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point toward intra-uterine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the brain of the fetus. The current available technology doesn't allow observing what is happening at cellular level since the human brain is not exposed  to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia. Methods. In 1977 we began a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic mothers in order to finding differences at cellular level in relation to controls. Results. In these studies we have observed within the nuclei of neurons the presence of complete and incomplete viral particles that reacted in positive form with antibodies to herpes simplex hominis type I [HSV1] virus, and mitochondria alterations. Conclusion. The importance of these findings can have practical applications in the prevention of the illness keeping in mind its direct relation to the aetiology and physiopathology of schizophrenia. A study of amniotic fluid cells in women at risk of having a schizophrenic offspring is considered. Of being observed the same alterations that those observed previously in the cells of the brain of the studied foetuses, it would intend to these women in risk of having a schizophrenia descendant, previous information of the results, the voluntary medical interruption of the pregnancy or an early anti HSV1 viral treatment as preventive measure of the later development of the illness.

Reza Nassiri

Michigan State University, USA

Title: Microbiome and Chronic Disorders
Speaker
Biography:

Dr. Nassiri is a former Associate Dean of Global Health at the Michigan State University (MSU). He also served as MSU director of Institute of International Health. He is currently Professor of Pharmacology and Toxicology, Professor of Family and Community Medicine, and, lecturer in Global Health, Infectious Diseases and Tropical Medicine. He currently works on international public health issues relating to chronic diseases and has expertise in global health. He has made contributions in various fields of medical sciences including clinical investigation and health education. On the basis of his extensive experience and expertise in chronic infectious diseases including HIV/AIDS, TB as well as antimicrobial resistance and human gut microbiome, he developed clinical research programs in Brazil, South Africa, Haiti, Dominican Republic and Mexico. He had served as editorial board member for the journal of HIV and AIDS Review. He is currently on editorial board member for AIDS Patient Care and STDs. Prof. Nassiri has delivered seminar presentations on Tropical Medicine, HIV/AIDS, TB, Global Health and public health interventions in numerous national and international conferences and workshops. He is internationally recognized for his work in the areas of building effective international partnerships particularly in global health, community health, clinical care capacity building, and technical assistance mechanism. He is the founder of Michigan State University Osteopathic and Primary Health Clinic in Merida, Yucatan, Mexico. He has developed academic and research partnership programs with Federal University of Para Institute of Tropical Medicine in Belem, Brazil.

Abstract:

The research and clinical interests for microbiota formerly called “the normal flora”, has grown tremendously in the recent years.  The large-scale dynamics of the microbiome can be described by many of the tools and observations used in the study and management of chronic disorders. Microbiome and metagenome have important functions in health and disease – their exploration is continuous to better understand human health and genetics, especially the announcement made by the U.S.  National Microbiome Initiative.  It is now understood that complex microbial communities can influence the pathology chronic diseases, which may have implications for disease diagnosis, management, and prognosis.  Currently, studies focus on investigations of variant microbiome communities such as cutaneous, gastric, colonic/colorectal, inflammatory bowel diseases, obesity and metabolic disease just to list few.   The key in application of microbiome in chronic disorders is the microbial restoration, which is an appropriate extension of the probiotic strategy – the microbial transplantation has received much interests in the recent years aiming at generating intact microbial community in a diseased person.  C. difficile recurrent infections and microbial restoration is a remarkable example of the application of microbial transplantation.  Therefore, it appears the future of microbiome therapeutic modalities is a targeted approach which may become embedded in the precision management chronic disorders.  Such an approach relies on host factors that may influence the overall individual health as well as response to treatment modalities (e.g., microbial restoration). However, another key factor to such a response is host genetics.  Advances in technology especially in nucleic acid sequencing and cultured based microbiology has helped the scientific community to better examine the new roles of microbes in both health and diseases.  In summary, advances in microbial phenotyping and metabolic profiling provides a new insight for developing novel therapies for chronic disease conditions.  Application of the plantation of microbiome communities may also help to prevent a range of chronic disorders.

Speaker
Biography:

Dr. Adeyemi Abati completed his MBBS in 2004 at Obafemi Awolowo University Teaching Hospital, Nigeria, he was trained at the department of inectious diseases during is residency. And he was able to provide several superior care and consultaion that resulted in overall improvement of department patient’s Satisfation quotient. Dr Adeyemi focused on patient’s treatment and re-evaluated several methods of therapy management dependant on infection types tailored to patient’s individual Patient history and efficacy of previous treatments. He  completed is master degree in public health at the same institution. He has then been practicing in Department of Infectious Disease at Lagos University Teaching Hospital, one of the top tree infection disease hospital in Nigeria and also doing his PhD at the moment. He currently holds a certification from Nigerian board of internal medicine for internal medicine ,hematology and infectious disease and also awarded the ward of the developing leader in medicine from Nigerian medical association in 2010 for his excellent contribution in general treatment and towards the reduction of infectious disease in Nigeria.

Abstract:

Aim: In Nigeria, Hepatitis C Virus (hcv) infection is primarily spread through injection drug use. There is an urgent need to improve access to care for hcv among persons with opioid use disorders who inject drugs. The purpose of our study was to determine the prevalence of hcv, patient characteristics, and receipt of appropriate care in a sample of patients treated with buprenorphine for their opioid use disorders in a primary care setting. Methods:This study used retrospective clinical data from the electronic medical record. The study population included patients receiving buprenorphine in the office based opioid treatment (obot) clinic within the adult primary medicine clinic at lagos medical center between october 2008 and august 2015 who received a conclusive hcv antibody ab test within a year of clinic entry. We compared characteristics by hcv serostatus using pearson's chi-square and provided numbers/percentages receiving appropriate care. Results: The sample comprised 300 patients. Slightly less than half of all patients (n = 134, 27.7%) were hcv ab positive, and were significantly more likely to be older hausas and yoruba’s, have diagnoses of post- traumatic stress disorder (ptsd) and bipolar disorder, have prior heroin or cocaine use, and be hi v- infected. Among the 134 hcv ab positive patients, 126 (67.7%) had detectable hcv ribonucleic acid (rna) indicating chronic hcv infection; only 8 patients (2.21%) with chronic hcv infection ever initiated treatment. Conclusions: Nearly half of patients (47.7%) receiving office-based treatment with buprenorphine for their opioid use disorder had a positive hepatitis c virus antibody screening test , although initiation of hcv treatment was nearly non-existent (2.21%).

Day 2 :

  • Chronic Illness and Mental health | Environmental Approaches | Risk Factors | Chronic Diseases Diagnosis

Session Introduction

Dr. Enkhtuya Palam

National Center for Public Health, Mongolia

Title: Smoking prevalence and determinants of cigarette use among the young people in Mongolia
Speaker
Biography:

Dr. Enkhtuya Palam, Lead Researcher of the National Center for Public Health Mongolia. She is a pediatrician, has always had the vocation to research, aware that only the improvement and innovation of its public services can be the right answer to the growing needs of community. She completed her degree in Public Health Sciences at the Medical University of Irkutsk, Russia in the year 2003. Her Postgraduate internship at Seoul National University in Korea, Lead Researcher of the National Center for Public Health from 1997 to present. Her research activity includes the NCD KAP survey since 2010 and 2012 and also National STEPS survey on prevalence of risk factors in 2005, 2009 and 2013.

Abstract:

Background: Cigarette use in the Western Pacific Region among school aged children is a growing public health concern. Surveillance of the prevalence of cigarette smoking among the youth in this region is the first step in a long process of implementing policy change and public health interventions to combat the widespread tobacco epidemic in this region. In addition to estimating the prevalence and determinants of cigarette use (in packs and singles) within a national sample of school aged children in Mongolia, this study determined how a child’s pocket money, familial and social contextual factors, and access to cigarette vendors influenced his/her smoking status. Methods: The 2014 Global Youth Tobacco Survey, a stratified multi-stage cluster design survey, was utilized to predict prevalence and determinants of cigarette use. Analysis was conducted using SAS-callable software SUDAAN to account for the design effect and increased homogeneity of within cluster groups. Prevalence and determinants of single cigarette use among current smokers was also estimated using the same variance estimation methods. Results: Cigarette use among school children was most evident in those children who were older, male, urban dwelling, with parents or friends who smoke. Cigarette use was almost two times more prevalent in urban than rural school children and, among urban school children who smoked, more than half purchased a single cigarette – an illicit product in Mongolia. Pocket money strongly influenced the purchase of cigarettes and single cigarettes.  A child’s choice to smoke cigarettes was associated with the sale of cigarettes (pack or single cigarette) near their school. Conclusion: The findings of this study provide evidence and information for the Mongolia Ministry of Health to use in future tobacco related policy change. Strong correlations between our variables of interest and cigarette use indicate that the WHO FCTC need to focus on further increasing the price of cigarettes and also enforce restriction of the sale of legal and illegal (packs and single cigarettes) cigarettes to minors.

Speaker
Biography:

Khaled M Alsubiaee is a healthcare professional researcher. Mr.  Alsubiaee has interest in different research area, including risk management, community related issues, public health, and Medicine. Recently, Alsubiaee joins Australasian Medical Journal (AMJ) as a reviewer.

Abstract:

Mental health had been recognized as one of the elements of health definition by world health organization. In Saudi Arabia, mental health provision still limited at primary health centers (PHC). Moreover, a high percentage of Saudi patients have mental disorders face a lower ability of primary health care center physicians to diagnose mental illness. Available knowledge and practice form society beliefs based on how things seem. This study describes the perception of Saudi society towards mentally ill people. Methods: A cross sectional study using modified questionnaire items includes 24 questions. A pilot study conducted using 30 participants to test reliability and validity. Total participants is 249, the questionnaires distributed using three ways: interview with 8 persons on public, 33 distributed research questionnaire papers and 208 electronically via Google forum and distributed by WhatsApp and twitter applications.  11 questionnaires are omitted due to incomplete answer of questions. Data collection done in Riyadh city in 2016, April 25th to May 7th. Result: Majority of respondents is male, living in Riyadh, not married and have an education higher than secondary school. The age of participants is 27± 9 years with most of them are not working. The majority of participants agrees that the mental ill person is able to work, can be treated outside of hospital, mental illness can affect anybody and they can accept the friendship of mentally ill person. On the other hand, a high percentage of participants disagree with mental illness never cured, feeling uncomfortable in sharing same working area, avoiding contact, becoming afraid when encountered in conversation with mentally ill person. Conclusion: The study shows that respondents are emotional towards mentally ill people in Saudi Arabia, but there are some of respondents consider mentally ill person as dangerous people and are not willing to marry to mentally ill person.